Invention Grant
- Patent Title: Generation of new BCG vaccine strains protecting against the establishment of latent Mycobacterium tuberculosis infection and reactivation from the latent or persistent state
- Patent Title (中): 产生新的BCG疫苗株，防止潜在的结核分枝杆菌感染的建立和潜在或持续状态的再激活
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Application No.: US11939144Application Date: 2007-11-13
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Publication No.: US07935354B2Publication Date: 2011-05-03
- Inventor: Mario Alberto Flores-Valdez , Gary K. Schoolnik , Michel Klein , Jerald C. Sadoff , David Hone
- Applicant: Mario Alberto Flores-Valdez , Gary K. Schoolnik , Michel Klein , Jerald C. Sadoff , David Hone
- Applicant Address: US MD Rockville US CA Palo Alto
- Assignee: Aeras Global TB Vaccine Foundation,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: Aeras Global TB Vaccine Foundation,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US MD Rockville US CA Palo Alto
- Agency: Whitham Curtis Christofferson & Cook, PC
- Main IPC: A61K39/04
- IPC: A61K39/04 ; A61K49/00 ; A61K39/00
Abstract:
A vaccine for treating or preventing the establishment of latent tuberculosis infections is provided. The vaccine comprises a recombinant mycobacterium that overexpresses the transcription factor DosR, at a level sufficient to induce production of the dosR regulon genes or proteins. A host to whom the vaccine is administered mounts an immune response to the dosR regulon proteins and is thus protected from the establishment, persistence or reactivation of latent tuberculosis.
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