Invention Grant
- Patent Title: Trp/his exchange and kynurenine induced Trp transport
- Patent Title (中): Trp /他的交换和kynurenine诱导Trp运输
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Application No.: US12040524Application Date: 2008-02-29
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Publication No.: US07935494B2Publication Date: 2011-05-03
- Inventor: Thijs Kaper , Michael Platten , Lawrence Steinman , Wolf Frommer
- Applicant: Thijs Kaper , Michael Platten , Lawrence Steinman , Wolf Frommer
- Applicant Address: US DC Washington US CA Palo Alto
- Assignee: Carnegie Institution of Washington,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: Carnegie Institution of Washington,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US DC Washington US CA Palo Alto
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: G01N33/53
- IPC: G01N33/53
Abstract:
The present invention provides methods for detecting changes in tryptophan concentrations in a cell and methods for identifying agents that modulate cellular tryptophan concentrations. In particular, the present invention provides methods for detecting cellular exchange between tryptophan and kynurenine, and methods for identifying agents that modulate this exchange. The present invention also provides methods for treating a disease associated with immunosuppression in a subject in need thereof. In particular, the present invention is directed toward a method of treating a disease associated with immunosuppression comprising contacting the disease with an agent that modulates cellular Trp/kynurenine exchange. Furthermore, the present invention provides methods for identifying an agent that modulates an immunosuppression.
Public/Granted literature
- US20080227140A1 TRP/HIS Exchange and Kynurenine Induced TRP Transport Public/Granted day:2008-09-18
Information query
IPC分类:
