Invention Grant
- Patent Title: Polyamides with tail structures capable of binding DNA
- Patent Title (中): 具有能够结合DNA的尾部结构的聚酰胺
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Application No.: US11998446Application Date: 2007-11-28
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Publication No.: US07935530B2Publication Date: 2011-05-03
- Inventor: Peter B. Dervan , Claire S. Jacobs , Nicholas G. Nickols , Daniel A. Harki
- Applicant: Peter B. Dervan , Claire S. Jacobs , Nicholas G. Nickols , Daniel A. Harki
- Applicant Address: US CA Pasedena
- Assignee: California Institute of Technology
- Current Assignee: California Institute of Technology
- Current Assignee Address: US CA Pasedena
- Agency: Stahl Law Firm
- Main IPC: C12N15/00
- IPC: C12N15/00 ; A61K38/04
Abstract:
The present invention relates to polyamides with a tail comprising a linker and an end-group. A preferred end-group is isophthalic acid and derivatives thereof. Polyamides of the invention are capable of entering the nucleus of cells. Polyamides of the invention are capable of selectively binding DNA. The invention also relates to methods of using the polyamides in therapy and research.
Public/Granted literature
- US20080269138A1 Polyamides with tail structures Public/Granted day:2008-10-30
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