Invention Grant
US07935685B2 Process for preparation of inclusion compounds between a non-steroidal anti-inflammatory drug and betacyclodextrin by microwave treatment
失效
通过微波处理制备非甾体抗炎药和betacyclodextrin之间的包合物的方法
- Patent Title: Process for preparation of inclusion compounds between a non-steroidal anti-inflammatory drug and betacyclodextrin by microwave treatment
- Patent Title (中): 通过微波处理制备非甾体抗炎药和betacyclodextrin之间的包合物的方法
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Application No.: US10499338Application Date: 2002-12-17
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Publication No.: US07935685B2Publication Date: 2011-05-03
- Inventor: Ferdinando Giordano , Ruggero Bettini
- Applicant: Ferdinando Giordano , Ruggero Bettini
- Applicant Address: IT Parma
- Assignee: Chiesi Farmaceutici S.p.A.
- Current Assignee: Chiesi Farmaceutici S.p.A.
- Current Assignee Address: IT Parma
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: ITM12001A2749 20011221
- International Application: PCT/EP02/14349 WO 20021217
- International Announcement: WO03/053475 WO 20030703
- Main IPC: A01N43/04
- IPC: A01N43/04 ; A61K31/715 ; A61K31/70 ; C07D279/00 ; C07D285/00 ; C07D295/00 ; C07D419/00 ; C07D513/00
Abstract:
A process for the preparation of inclusion complexes of a drug (piroxicam or ibuprofen) and a cyclodextrin, characterised in that: a) the drug and cyclodextrin, in the form of finely divided powders, are mixed in the presence of aqueous or hydroalcoholic solutions, ammonia solutions or acid solutions; b) the resulting mixture is treated in a microwave oven; c) the resulting product is dried under vacuum at room temperature or with heating.
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