Invention Grant
- Patent Title: Use of triglyceride oils containing γ-linolenic acid residues and linoleic acid residues for the treatment of neurodegenerative disease
- Patent Title (中): 含有γ-亚麻酸残基和亚油酸残基的甘油三酯油用于治疗神经变性疾病
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Application No.: US10555757Application Date: 2004-05-14
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Publication No.: US07935729B2Publication Date: 2011-05-03
- Inventor: Laurence S. Harbige , Michael J. Leach , Mohammed Sharief
- Applicant: Laurence S. Harbige , Michael J. Leach , Mohammed Sharief
- Applicant Address: GB London
- Assignee: BTG International Limited
- Current Assignee: BTG International Limited
- Current Assignee Address: GB London
- Agency: Nixon & Vanderhye
- Priority: GB0311081.4 20030514
- International Application: PCT/GB2004/002089 WO 20040514
- International Announcement: WO2004/100943 WO 20041125
- Main IPC: A61K31/22
- IPC: A61K31/22 ; A61K31/07
Abstract:
Method for treating a patient in need of therapy for a neurodegenerative disease by administering to that patient a therapeutically effective dose of a triglyceride oil containing both γ-linolenic acid and linolenic acid residues as triglyceride ester. The ratio of γ-linolenic acid to linolenic acid residues at the sn-2 position of the triglyceride is at least 0.8. The amount of γ-linolenic acid residues at the sn-2 position is at least 18%. The oil is administered at a dose sufficient to maintain or elevate TGF-β1 levels in the patient at a therapeutic level.
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