Invention Grant
US07935791B2 Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
有权
拮抗剂抗Notch3抗体及其在预防和治疗Notch3相关疾病中的应用
- Patent Title: Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases
- Patent Title (中): 拮抗剂抗Notch3抗体及其在预防和治疗Notch3相关疾病中的应用
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Application No.: US11958099Application Date: 2007-12-17
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Publication No.: US07935791B2Publication Date: 2011-05-03
- Inventor: Sek Chung Fung , Kang Li , Yucheng Li , Sanjaya Singh , Bin-Bing Stephen Zhou
- Applicant: Sek Chung Fung , Kang Li , Yucheng Li , Sanjaya Singh , Bin-Bing Stephen Zhou
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Danielle M. Pasqualone
- Main IPC: C07K16/30
- IPC: C07K16/30
Abstract:
The present invention relates to antagonist antibodies that specifically bind to Notch 3 and inhibit its activation. The present invention includes antibodies binding to a conformational epitope comprising the first Lin12 domain and the second dimerization domain. The present invention also includes uses of these antibodies to treat or prevent Notch 3 related diseases or disorders.
Public/Granted literature
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