Invention Grant
- Patent Title: Methods for N-demethylation of morphine and tropane alkaloids
- Patent Title (中): 吗啡和托烷生物碱的N-去甲基化方法
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Application No.: US11771227Application Date: 2007-06-29
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Publication No.: US07935820B2Publication Date: 2011-05-03
- Inventor: Robert James Carroll , Hannes Leisch , Tomas Hudlicky
- Applicant: Robert James Carroll , Hannes Leisch , Tomas Hudlicky
- Applicant Address: CA St. Catharines
- Assignee: Brock University
- Current Assignee: Brock University
- Current Assignee Address: CA St. Catharines
- Agency: Occhiuti Rohlicek & Tsao LLP
- Main IPC: C07D489/02
- IPC: C07D489/02 ; C07D489/08
Abstract:
The present invention provides a method for the N-demethylation of an N-methylated heterocycle, particularly a morphine or tropane alkaloid or derivative thereof. The method comprises reacting the heterocycle with a metal catalyst and a solvent in the presence of an oxidizing agent.
Public/Granted literature
- US20090005564A1 METHODS FOR N-DEMETHYLATION OF MORPHINE AND TROPANE ALKALOIDS Public/Granted day:2009-01-01
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