The present invention extends to methods, systems, and computer program products for recognizing selection regions from multiple simultaneous inputs. Input selection regions are calculated from simultaneous contacts on a multi-touch input display surface. Computer system users can use natural and/or more intuitive hand gestures to select items on an input/display surface. Selection regions can be dynamically adjusted to in response to detected changes in contact at different locations on a surface. For example, selection region changes can be updated in essentially real-time as fingers are added and moved on the multi-touch input display surface. The calculation of selection regions can vary based on an application and/or operating system context.