Methods and apparatus to perform frequency-domain equalization in high-speed downlink packet access (HSDPA) receivers for wireless channels with large delay-spreads are disclosed. An example method comprises computing a first frequency-domain equalizer (FDE) coefficient for a first set of multipaths, computing a second FDE coefficient for a second set of multipaths, computing a first equalized signal by equalizing a received code division multiple access (CDMA) signal with the first FDE coefficient, computing a second equalized signal by equalizing the received CDMA signal with the second FDE coefficient, delaying the first equalized signal by a delay difference between the first and the second sets, and combining the delayed first equalized signal and the second equalized signal.