Model-based production control systems and methods are presented for constructing plans for controlling operation of a production system with a plant having a plurality of resources to achieve one or more production goals, in which a planner constructs plans for execution in the plant based on production goals while balancing both production objectives (e.g., production cost, production time) and diagnostic objectives (e.g., diagnostic cost, information gained, repair cost), and a diagnosis engine determines a current plant condition based on a previously executed plan and corresponding observations from the plant, and provides expected information gain data to the planner, with the planner generating a plan that will achieve a given production goal and is improved for one or more diagnostic objectives and the expected information gain data.