A safety sign that has a front panel with cut out letters or numbers that form the word or message of the sign. Behind the front panel a predetermined distance can be a reflective panel or other surface. Light from an oncoming vehicle can reflect from this reflective panel through the cut out letters causing the sign to function like any other safety sign when not lighted. One or more light sources like LEDs can be mounted facing the reflective panel at angles so that light from these sources is reflected from the reflective panel and out through the cut out letters causing the sign to increase significantly in visibility at night or in other low light conditions. Further light sources can be located around the periphery of the sign or around the word or words on the sign. All or part of the light sources can be made to blink, and the system can optionally be made to turn off during the daytime. The sign can be run from AC power or battery power. An optional solar panel can charge the battery during the daytime.