A vacuum sealing bag includes first and second bag panels overlappedly affixed in an edge to edge manner to form a storing cavity between the first and second bag panels and an opening communicating with the storing cavity, and an air sealing arrangement having a plurality of first air channels longitudinally formed on an inner side of the first bag panel and a plurality of second air channels transversely formed on an inner side of the second bag panel in such a manner that when the inner side of the first bag panel is overlapped on the inner side of the second bag panel, the first air channels are communicatively intersected with the second air channels for guiding air within the storing cavity to outside, so as to air-seal the storing cavity in a vacuum manner.