Invention Grant
US07939052B2 Method of measuring the biological activity of an urotensin II receptor
有权
测量泌尿生素II受体的生物活性的方法
- Patent Title: Method of measuring the biological activity of an urotensin II receptor
- Patent Title (中): 测量泌尿生素II受体的生物活性的方法
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Application No.: US11432465Application Date: 2006-05-11
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Publication No.: US07939052B2Publication Date: 2011-05-10
- Inventor: Robert Schulingkamp , Jianshen Qi , Raymond Colburn , Dennis Stone , Christopher Van Besien , Lisa Minor , Patricia Andrade-Gordon , Bruce Damiano
- Applicant: Robert Schulingkamp , Jianshen Qi , Raymond Colburn , Dennis Stone , Christopher Van Besien , Lisa Minor , Patricia Andrade-Gordon , Bruce Damiano
- Applicant Address: BE
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE
- Main IPC: A61K49/00
- IPC: A61K49/00 ; A61K38/17
Abstract:
Administration of U-II to rats caused an increase in the redness or the skin temperature of the ear of the rats. The increase was inhibited by compounds that decease the biological activity of the U-II/UT receptor. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the redness or the skin temperature of the ear of an animal, and the use of the methods to test compounds for their abilities to increase or decrease the biological activity of an U-II receptor.
Public/Granted literature
- US20060280686A1 Method of measuring the biological activity of an urotensin II receptor Public/Granted day:2006-12-14
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