Invention Grant
US07939089B2 Attenuated mycobacteria as vectors for gene delivery to mammalian cells
失效
减毒分枝杆菌作为哺乳动物细胞基因递送载体
- Patent Title: Attenuated mycobacteria as vectors for gene delivery to mammalian cells
- Patent Title (中): 减毒分枝杆菌作为哺乳动物细胞基因递送载体
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Application No.: US11794372Application Date: 2006-01-12
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Publication No.: US07939089B2Publication Date: 2011-05-10
- Inventor: William R. Jacobs, Jr. , Glenn J. Fennelly
- Applicant: William R. Jacobs, Jr. , Glenn J. Fennelly
- Applicant Address: US NY Bronx
- Assignee: Albert Einstein College of Medicine of Yeshiva University
- Current Assignee: Albert Einstein College of Medicine of Yeshiva University
- Current Assignee Address: US NY Bronx
- Agency: Amster, Rothstein & Ebenstein LLP
- International Application: PCT/US2006/001130 WO 20060112
- International Announcement: WO2006/076517 WO 20060720
- Main IPC: A61K39/40
- IPC: A61K39/40 ; A61K39/02 ; A61K39/00
Abstract:
Provided are mycobacteria comprising a recombinant gene operably liked to a mammalian promoter that directs expression of the recombinant gene from a mammalian cell. Also provided are mammalian cells comprising the above mycobacteria. Additionally provided are mycobacterial plasmids capable of replication in a mycobacterium. Further provided are methods of expressing a recombinant gene in a mammalian cell.
Public/Granted literature
- US20080268541A1 Attenuated Mycobacteria as Vectors for Gene Delivery to Mammalian Cells Public/Granted day:2008-10-30
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