Invention Grant
US07939253B2 Methods and compositions for the diagnosis and treatment of ewing's sarcoma
有权
用于诊断和治疗尤文氏肉瘤的方法和组合物
- Patent Title: Methods and compositions for the diagnosis and treatment of ewing's sarcoma
- Patent Title (中): 用于诊断和治疗尤文氏肉瘤的方法和组合物
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Application No.: US11746376Application Date: 2007-05-09
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Publication No.: US07939253B2Publication Date: 2011-05-10
- Inventor: Stephen L. Lessnick
- Applicant: Stephen L. Lessnick
- Applicant Address: US UT Salt Lake City
- Assignee: The University of Utah Research Foundation
- Current Assignee: The University of Utah Research Foundation
- Current Assignee Address: US UT Salt Lake City
- Agency: Foley & Lardner LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; A61K48/00
Abstract:
The present invention relates to methods and compositions for the detection and treatment of Ewing's sarcoma. In particular, the methods of detection relate to measuring in Ewing's sarcoma cells the expression of the NKX2.2 gene, as well as targets genes downstream of NKX2.2. The compositions and method of treatment for Ewing's sarcoma involve therapeutic agents that target the expression of the NKX2.2 gene or block the activity of the NKX2.2 protein. Also provided are methods of screening therapeutic agents that affect the expression of the NKX2.2 gene.
Public/Granted literature
- US20080280844A1 METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF EWING'S SARCOMA Public/Granted day:2008-11-13
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