Invention Grant
- Patent Title: Method for the diagnosis of schizophrenia
- Patent Title (中): 精神分裂症诊断方法
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Application No.: US12490195Application Date: 2009-06-23
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Publication No.: US07939262B2Publication Date: 2011-05-10
- Inventor: Sara Fuchs , Tal Ilani , Orly Perl
- Applicant: Sara Fuchs , Tal Ilani , Orly Perl
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- Agency: Browdy and Neimark, PLLC
- Priority: IL137865 20000815
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12P19/34 ; C07H21/02

Abstract:
A method for the diagnosis of schizophrenia in an individual comprises: (i) measuring mRNA of either D3 dopamine receptor or α7 nicotinic acetylcholine receptor (α7 AChR), and of a control gene in peripheral blood lymphocytes (PBLs) of the individual and of at least one healthy control individual; (ii) calculating the ratio between the receptor mRNA and the control gene mRNA for each individual; and (iii) evaluating the ratio between the ratios obtained in (ii) for the tested individual and for the at least one healthy control individual, wherein (a) an increase in the D3 dopamine receptor mRNA or a decrease in the α7 AChR in the tested individual in comparison to healthy individuals, indicates that said tested individual has a higher likelihood of having schizophrenia than the healthy controls.
Public/Granted literature
- US20100041043A1 METHOD FOR THE DIAGNOSIS AND FOLLOW-UP OF SCHIZOPHRENIA AND OTHER MENTAL AND NEUROLOGICAL DISORDERS Public/Granted day:2010-02-18
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