Invention Grant
US07939558B2 Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
有权
通过突变体CFTR增加离子迁移活性的化合物及其用途
- Patent Title: Compounds having activity in increasing ion transport by mutant-CFTR and uses thereof
- Patent Title (中): 通过突变体CFTR增加离子迁移活性的化合物及其用途
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Application No.: US11628411Application Date: 2005-06-02
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Publication No.: US07939558B2Publication Date: 2011-05-10
- Inventor: Alan Verkman , R. Kiplin Guy , Nicoletta Pedemonte , Luis J. V. Galietta
- Applicant: Alan Verkman , R. Kiplin Guy , Nicoletta Pedemonte , Luis J. V. Galietta
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Carol L. Francis; Connie C. Tong
- International Application: PCT/US2005/019346 WO 20050602
- International Announcement: WO2005/120497 WO 20051222
- Main IPC: A61K31/404
- IPC: A61K31/404 ; C07D209/04
Abstract:
The invention provides compositions, pharmaceutical preparations and methods for increasing activity (e.g., ion transport) of the mutant cystic fibrosis transmembrane conductance regulator protein (mutant-CFTR), e.g., ΔF508 CFTR, G551D-CFTR, G1349D-CFTR, or D1152H-CFTR, that are useful for the treatment of cystic fibrosis (CF). The compositions and pharmaceutical preparations of the invention may comprise one or more phenylglycine-containing compounds or sulfonamide-containing compounds of the invention, or an analog or derivative thereof.
Public/Granted literature
- US20080319008A1 Compounds Having Activity in Increasing Ion Transport by Mutant-Cftr and Uses Thereof Public/Granted day:2008-12-25
Information query
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