Invention Grant
- Patent Title: Oligocarbonate molecular transporters
- Patent Title (中): 低聚碳酸酯分子转运蛋白
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Application No.: US12433693Application Date: 2009-04-30
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Publication No.: US07939621B2Publication Date: 2011-05-10
- Inventor: Christina Cooley , James Lupton Hedrick , Matthew Kiesewetter , Fredrik Nederberg , Brian Trantow , Robert Waymouth , Paul Wender
- Applicant: Christina Cooley , James Lupton Hedrick , Matthew Kiesewetter , Fredrik Nederberg , Brian Trantow , Robert Waymouth , Paul Wender
- Applicant Address: US NY Armonk US CA Stanford
- Assignee: International Business Machines Corporation,Stanford University
- Current Assignee: International Business Machines Corporation,Stanford University
- Current Assignee Address: US NY Armonk US CA Stanford
- Agency: Shumaker & Sieffert, P.A.
- Main IPC: C08G64/00
- IPC: C08G64/00 ; C08G63/02

Abstract:
A cyclic carbonate monomer, including: wherein R1, R2, and R3 are independently selected from the group consisting of H, linear or branched, substituted or unsubstituted alkyl; R10 is a connecting group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; R4 is an optional bridging group selected from the group consisting of linear or branched, substituted or unsubstituted alkyl, heteroalkyl, cycloalkyl, heterocyclic, aryl and heteroaryl; Z is selected from the group consisting of O, NH, NR, and S; G is a guanidine group; and P is a protecting group. The cylic carbonate monomer can be reacted with an initiator including a drug, drug candidate, probe or other molecule of interest to form an oligomer with the molecule of interest attached to one end of a carbonate backbone and guanidine groups attached to the carbonate backbone.
Public/Granted literature
- US20100280219A1 OLIGOCARBONATE MOLECULAR TRANSPORTERS Public/Granted day:2010-11-04
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