An awareness detection system and method are provided. The system includes an imaging device positioned to obtain a plurality of images of at least a portion of a subject's head, and an awareness processor in communication with the imaging device. The awareness processor receives an image from the imaging device and performs the steps including conducting a two-point head pose analysis when two eyes of the subject are located, conducting a one-point head pose analysis when only one eye of the subject is located, and conducting a zero-point head pose analysis when zero eyes of the subject are located. The awareness processor further performs the steps of detecting at least one point of interest in the image, conducting a motion analysis of the image to estimate a head pose of the subject, and determining a state of awareness of the subject.