Disclosed is a method of minimizing clock uncertainty using a multi-level de-skewing technique. The method includes the steps of obtaining a chip wherein at least a portion of the chip has a regular array of buffers on multiple levels, the buffers being driven by first drivers and the first drivers being driven by second drivers; grouping the buffers in a first direction to create clusters with the same number of buffer inputs, wherein if there are not the same number of buffer inputs in each cluster, then adding dummy buffers to the cluster with a deficient number of buffer inputs; wiring outputs of the first drivers together in a second direction, wherein the first and second directions are orthogonal; and wiring outputs of the second together in the second direction.