Invention Grant
- Patent Title: Methods of modulating angiogenesis
- Patent Title (中): 调节血管发生的方法
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Application No.: US11879655Application Date: 2007-07-17
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Publication No.: US07947278B2Publication Date: 2011-05-24
- Inventor: Calvin Jay Kuo , Frank Kuhnert
- Applicant: Calvin Jay Kuo , Frank Kuhnert
- Applicant Address: US CA Palo Alto
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Palo Alto
- Agency: Bozicevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- Main IPC: A61K39/38
- IPC: A61K39/38 ; A61K31/00 ; A61K38/00 ; A01N61/00 ; A01N37/18
Abstract:
The present invention provides methods of modulating angiogenesis in an individual, the methods generally involving administering to an individual an agent that modulates the expression or activity of Egfl7, where an agonist of Egfl7, including an Egfl7 polypeptide, decreases angiogenesis. In one embodiment, the methods of the invention relate to inhibiting pathological angiogenesis by enhancing activity of Egfl7, which method may be carried out in conjunction with administration of one or more other anti-angiogenic agents.
Public/Granted literature
- US20080113911A1 Methods of modulating angiogenesis Public/Granted day:2008-05-15
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