Invention Grant
- Patent Title: Peptide having hydrolase activity
- Patent Title (中): 具有水解酶活性的肽
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Application No.: US11477771Application Date: 2006-06-29
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Publication No.: US07947279B2Publication Date: 2011-05-24
- Inventor: Ottavio Arancio , Michael L. Shelanski , Bing Gong
- Applicant: Ottavio Arancio , Michael L. Shelanski , Bing Gong
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Wilmer Cutler Pickering Hale and Dorr, LLP
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/385 ; C07K1/00
Abstract:
The invention is directed to methods for increasing learning and memory in a subject with a neuropathological condition, specifically a condition related to elevated beta-amyloid deposition, the method comprising administering to the subject an effective amount of a compound capable of increasing the activity of Uch-L1. The invention is also directed to screening methods for identifying compounds that enhance the activity of the proteasome system, Uch-L1, or both.
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