Invention Grant
- Patent Title: Protease-resistant modified SEB and vaccine containing the same
- Patent Title (中): 蛋白酶抗性修饰SEB和含有相同的疫苗
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Application No.: US12644952Application Date: 2009-12-22
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Publication No.: US07947290B2Publication Date: 2011-05-24
- Inventor: Toshihiro Nakashima , Takumi Sasaki , Tsukasa Nishihara , Sumiyo Takemoto , Atsuko Sakata , Masao Ohkuchi , Tomoyuki Koshi , Toshiyuki Edano
- Applicant: Toshihiro Nakashima , Takumi Sasaki , Tsukasa Nishihara , Sumiyo Takemoto , Atsuko Sakata , Masao Ohkuchi , Tomoyuki Koshi , Toshiyuki Edano
- Applicant Address: JP Kumamoto-shi JP Nagoya-shi
- Assignee: Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute,Kowa Company, Ltd.
- Current Assignee: Juridical Foundation, The Chemo-Sero-Therapeutic Research Institute,Kowa Company, Ltd.
- Current Assignee Address: JP Kumamoto-shi JP Nagoya-shi
- Agency: Browdy and Neimark, PLLC
- Priority: JP2003-314187 20030905
- Main IPC: A61K39/085
- IPC: A61K39/085 ; A61K39/09 ; C07K1/00 ; C07K14/00 ; C07K17/00

Abstract:
A modified Staphylococcal enterotoxin B (SEB) having resistance to a protease and a reduced toxicity and a vaccine comprising said modified SEB are provided. A modified SEB which has an amino acid sequence as set forth in SEQ ID NO: 1 wherein each of the lysine at 97-position and the lysine at 98-position are substituted with any other amino acid, or a derivative thereof and a vaccine comprising said modified SEB or a derivative thereof.
Public/Granted literature
- US20100166793A1 PROTEASE-RESISTANT MODIFIED SEB AND VACCINE CONTAINING THE SAME Public/Granted day:2010-07-01
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