Invention Grant
- Patent Title: Methods for making proteins containing free cysteine residues
- Patent Title (中): 制备含有游离半胱氨酸残基的蛋白质的方法
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Application No.: US12604165Application Date: 2009-10-22
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Publication No.: US07947655B2Publication Date: 2011-05-24
- Inventor: George N. Cox, III , Daniel H. Doherty , Mary S. Rosendahl
- Applicant: George N. Cox, III , Daniel H. Doherty , Mary S. Rosendahl
- Applicant Address: US CO Boulder
- Assignee: Bolder Biotechnology, Inc.
- Current Assignee: Bolder Biotechnology, Inc.
- Current Assignee Address: US CO Boulder
- Agency: Sheridan Ross P.C.
- Main IPC: A61K38/21
- IPC: A61K38/21 ; C07K14/56
Abstract:
The present invention relates to novel methods of making soluble proteins having free cysteines in which a host cell is exposed to a cysteine blocking agent. The soluble proteins produced by the methods can then be modified to increase their effectiveness. Such modifications include attaching a PEG moiety to form pegylated proteins.
Public/Granted literature
- US20100048872A1 METHODS FOR MAKING PROTEINS CONTAINING FREE CYSTEINE RESIDUES Public/Granted day:2010-02-25
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