Invention Grant
- Patent Title: Gene disruptions, compositions and methods relating thereto
- Patent Title (中): 基因破坏，组合物和方法
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Application No.: US11577547Application Date: 2005-10-18
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Publication No.: US07947866B2Publication Date: 2011-05-24
- Inventor: Mary Jean Sparks
- Applicant: Mary Jean Sparks
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Arnold & Porter LLP
- Agent Bonny Yeung; Christopher De Vry
- International Application: PCT/US2005/037291 WO 20051018
- International Announcement: WO2006/049854 WO 20060511
- Main IPC: G01N33/00
- IPC: G01N33/00
Abstract:
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO194, PRO220, PRO241, PRO284, PRO331, PRO354, PRO355, PRO533, PRO541, PRO725, PRO937, PRO1014, PRO1120, PRO1182, PRO1325, PRO1382, PRO1410, PRO1555, PRO1556, PRO1760, PRO1787, PRO1868, PRO4326, PRO4332, PRO4346, PRO4400, PRO6003, PRO6094, PRO6244, PRO9820, PRO9828, PRO10274, PRO16090, PRO19644, PRO21340, PRO92165, PRO85143, PRO1124, PRO1026 or PRO23370 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
Public/Granted literature
- US20090196876A1 Novel Gene Disruptions, Compositions and Methods Relating Thereto Public/Granted day:2009-08-06
Information query
