Certain aspects of a method and system for processing status blocks based on interrupt mapping may be disclosed. Exemplary aspects of the method may include determining whether a particular status block has been processed by at least one CPU based on comparing a value of a first register with a value of a second register, wherein the first register may comprise a running index value of at least one client segment within the particular status block and the second register may comprise a current running index value of at least one client segment. An interrupt may be generated, if the value of the first register is not equal to the value of the second register. The particular status block may be processed by at least one CPU based on the generated interrupt.