Invention Grant
US07951793B2 Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
有权
用作抗糖尿病和抗肥胖剂的取代的杂环衍生物和方法
- Patent Title: Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
- Patent Title (中): 用作抗糖尿病和抗肥胖剂的取代的杂环衍生物和方法
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Application No.: US11779319Application Date: 2007-07-18
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Publication No.: US07951793B2Publication Date: 2011-05-31
- Inventor: Peter T. W. Cheng , Sean Chen , Pratik Devasthale , Charles Z. Ding , Timothy F. Herpin , Shung Wu , Hao Zhang , Wei Wang , Xiang-Yang Ye
- Applicant: Peter T. W. Cheng , Sean Chen , Pratik Devasthale , Charles Z. Ding , Timothy F. Herpin , Shung Wu , Hao Zhang , Wei Wang , Xiang-Yang Ye
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Burton Rodney
- Main IPC: A61K31/397
- IPC: A61K31/397 ; C07D205/08 ; A01N43/00
Abstract:
Compounds are provided which have the structure wherein Z1 is (CH2)q or C═O; Z2 is (CH2)p or C═O; D is —CH═ or C═O or (CH2)m where m is 0, 1, 2 or 3; n=0, 1 or 2; p=1 or 2; q=0, 1 or 2; Q is C or N; X is CH or N; X2 is C, N, O or S; X3 is C, N, O or S; X4 is C, N, O or S; X5 is C, N, O or S; X6 is C, N, O or S; provided that at least one of X2, X3, X4 X5 and X6 is N; and at least one of X2, X3, X4 X5 and X6 is C; and A, B, R1, R2, R2a, R4, R3, E, Z and Y are as defined herein, which compounds are useful in treating diabetes and related diseases.
Public/Granted literature
- US20070287713A1 SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL AS ANTIDIABETIC AND ANTIOBESITY AGENTS AND METHOD Public/Granted day:2007-12-13
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