Invention Grant
US07951912B2 Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same
有权
来自功能化的β-内酰胺单体的聚合物和包含其的抗菌组合物
- Patent Title: Poly-β-peptides from functionalized β-lactam monomers and antibacterial compositions containing same
- Patent Title (中): 来自功能化的β-内酰胺单体的聚合物和包含其的抗菌组合物
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Application No.: US11510017Application Date: 2006-08-25
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Publication No.: US07951912B2Publication Date: 2011-05-31
- Inventor: Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
- Applicant: Shannon S. Stahl , Samuel H. Gellman , Sarah Lee , Mehmet F. Ilker , Bernard Weisblum , Denis Kissounko
- Applicant Address: US WI Madison
- Assignee: Wisconsin Alumni Research Foundation
- Current Assignee: Wisconsin Alumni Research Foundation
- Current Assignee Address: US WI Madison
- Agency: DeWitt Ross & Stevens S.C.
- Agent Joseph T. Leone, Esq.
- Main IPC: C12P21/06
- IPC: C12P21/06 ; C07K1/02
Abstract:
Disclosed is a method of making β-polypeptides. The method includes polymerizing β-lactam-containing monomers in the presence of a base initiator and a co-initiator which is not a metal-containing molecule to yield the product β-polypeptides. Specifically disclosed are methods wherein the base initiator is potassium t-butoxide, lithium bis(trimethylsilyl)amide (LiN(TMS)2), potassium bis(trimethyl-silyl)amide, and sodium ethoxide, and the reaction is carried out in a solvent such as chloroform, dichloromethane, dimethylsulfoxide, or tetrahydrofuran.
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