Invention Grant
US07951930B2 Cultured Xenopus laevis cell lines expressing mutant adenomatous polyposis coli gene
失效
培养表达突变型腺瘤性息肉病基因的非洲爪蟾细胞系
- Patent Title: Cultured Xenopus laevis cell lines expressing mutant adenomatous polyposis coli gene
- Patent Title (中): 培养表达突变型腺瘤性息肉病基因的非洲爪蟾细胞系
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Application No.: US12053198Application Date: 2008-03-21
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Publication No.: US07951930B2Publication Date: 2011-05-31
- Inventor: Yuko Kiyosue , Hiroyuki Sasaki , Shoichiro Tsukita
- Applicant: Yuko Kiyosue , Hiroyuki Sasaki , Shoichiro Tsukita
- Applicant Address: JP Tokyo
- Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee: Eisai R&D Management Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agency: Kilpatrick Townsend & Stockton LLP
- Priority: JP2002-241487 20020822
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C07H21/02 ; C12N15/00 ; C12N5/00
Abstract:
Using protein visualization techniques, cell lines stably expressing GFP-fused full-length and mutant APCs were obtained from cultured Xenopus laevis renal epithelial A6 cells. The use of these cells showed that mutant APCs, whose C-terminal region is absent, induced piling up of cells. Furthermore, piled up cells from mutant APC-expressing cell lines were proven to maintain the intercellular adhesive structure, representing a phenomenon similar to polyp formation in individual organisms (mice).
Public/Granted literature
- US20100003747A1 CULTURED XENOPUS LAEVIS CELL LINES EXPRESSING MUTANT ADENOMATOUS POLYPOSIS COLI GENE Public/Granted day:2010-01-07
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