Invention Grant
- Patent Title: Nucleic acid encoding sodium channel SCN3A alpha subunits
- Patent Title (中): 核酸编码钠通道SCN3Aα亚基
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Application No.: US12364166Application Date: 2009-02-02
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Publication No.: US07951931B2Publication Date: 2011-05-31
- Inventor: Guy A. Rouleau , Ronald G. Lafrenière , Daniel Rochefort
- Applicant: Guy A. Rouleau , Ronald G. Lafrenière , Daniel Rochefort
- Applicant Address: CA Montreal
- Assignee: McGill University
- Current Assignee: McGill University
- Current Assignee Address: CA Montreal
- Agent Goudreau Gage Dubuc; Charles Goyer
- Main IPC: C07H21/00
- IPC: C07H21/00 ; C12N15/00 ; C12N15/09 ; C12N15/12 ; C12N5/16 ; C12N1/15 ; C12N1/21
Abstract:
The present invention relates to epilepsy. More particularly, the present invention relates to idiopathic generalized epilepsy (IGE) and to the identification of three genes mapping to chromosome 2, which show mutations in patients with epilepsy. The invention further relates to nucleic acid sequences, and protein sequences of these loci (SCNA) and to the use thereof to assess, diagnose, prognose or treat epilepsy, to predict an epileptic individual's response to medication and to identify agents which modulate the function of the SCNA. The invention also provides screening assays using SCN1A, SCN2A and/or SCN3A which can identify compounds which have therapeutic benefit for epilepsy and related neurological disorders.
Public/Granted literature
- US20090148855A1 NUCLEIC ACID ENCODING OR TARGETING SODIUM CHANNEL SCN3A ALPHA SUBUNITS Public/Granted day:2009-06-11
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