Methods for using a client agent to route client requests among a plurality of appliances using transport layer information include the steps of: establishing, by a client agent executing on a client, a first transport layer connection with a first appliance of a plurality of appliances, the first appliance providing access to one or more servers; establishing, by a client agent executing on the client, a second transport layer connection with a second appliance of a plurality of appliances, the second appliance providing access to one or more servers; intercepting, by the client agent, a packet transmitted by the client; selecting, by the client agent, one of the connections to transmit the intercepted packet based on a characteristic of at least one of: the transport layer connections, the plurality of appliances, or the servers; and transmitting the intercepted packet via the selected connection.