A robotic medical system for use with an intravascular catheter that delivers fluid within an anatomical vessel is provided. The robotic medical system comprises a user interface configured for receiving at least one command, an electromechanical driver configured for being coupled to the catheter, a fluid delivery controller coupled to the catheter, and an electric controller configured for directing the electromechanical driver to mechanically move the catheter within at least one degree-of-freedom and for directing the fluid delivery controller to deliver fluid to the catheter in response to the at least one command. The robotic medical system may further comprise a source of fluid and a fluid line configured for coupling the source of fluid to the catheter, and a manifold configured for fluidly interfacing with the catheter, in which case, the manifold has a fluid inlet port coupled to the fluid line.