The invention provides a system and method for deploying a stent and infusing a therapeutic agent into tissue adjacent to the ends of the stent. The system comprises a catheter, an inflatable balloon, a stent, and a plurality of infusion elements. The catheter has an inflation lumen and at least one therapeutic agent delivery lumen. The balloon is disposed on the catheter and is in fluid communication with the inflation lumen. The stent is disposed on the balloon. The infusion elements are positioned adjacent to distal and proximal ends of the stent and are in fluid communication with at least one therapeutic agent delivery lumen. The infusion elements are inserted into a wall of a target region of a vessel responsive to inflation of the balloon. Further inflation of the balloon deploys the stent within the target region.