The disclosure provides for a chemical reaction-based thermal management system and method. The system comprises a heat source for heating a first flow element, a heat exchanger for transferring heat from the first flow element to a reaction mixture flow, and a heat sink comprising one or more endothermic chemical reactions to absorb heat from the heat exchanger. The system further comprises a reactor element for approaching chemical equilibrium of the reaction mixture flow, a product removal element for removing one or more products from the one or more endothermic chemical reactions, and a plurality of driver elements for moving the first flow element and for moving the reaction mixture flow.