Cathodes suitable for use in direct methanol fuel cells are disclosed. A cathode can comprise a composition supported on a conductive substrate, where the composition comprises: reactive nano-particles each consisting essentially of a core of metal and/or metal alloy and a shell of an oxide of the metal and/or metal alloy in the core; platinum and/or platinum alloy particles devoid of an oxide shell; and an ionomer. The metal nanoparticles can comprise one or more of palladium, chromium, manganese, nickel, iron, copper, gold, lanthanum, cerium, tin, sulfur, selenium, cobalt, silver, and alloys thereof. Direct methanol fuel cell incorporating these cathodes are also disclosed.