Invention Grant
- Patent Title: Nucleic acid encoding a self-assembling split-fluorescent protein system
- Patent Title (中): 编码自组装分裂荧光蛋白体系的核酸
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Application No.: US10973693Application Date: 2004-10-25
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Publication No.: US07955821B2Publication Date: 2011-06-07
- Inventor: Geoffrey S. Waldo , Stephanie Cabantous
- Applicant: Geoffrey S. Waldo , Stephanie Cabantous
- Applicant Address: US NM Los Alamos
- Assignee: Los Alamos National Security, LLC
- Current Assignee: Los Alamos National Security, LLC
- Current Assignee Address: US NM Los Alamos
- Agent Kenneth K. Sharples
- Main IPC: C12P21/02
- IPC: C12P21/02
Abstract:
The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with various combinations of self-complementing fragments derived from Aequorea victoria Green Fluorescent Protein (GFP), which are used to detect and quantify protein solubility in multiple assay formats, both in vitro and in vivo.
Public/Granted literature
- US20050221343A1 Self-assembling split-fluorescent protein systems Public/Granted day:2005-10-06
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