Invention Grant
US07955835B2 Stereoselective process for the production of dioxolane nucleoside analogues
有权
用于生产二氧戊环核苷类似物的立体选择性方法
- Patent Title: Stereoselective process for the production of dioxolane nucleoside analogues
- Patent Title (中): 用于生产二氧戊环核苷类似物的立体选择性方法
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Application No.: US10535235Application Date: 2003-11-18
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Publication No.: US07955835B2Publication Date: 2011-06-07
- Inventor: Alex Cimpoia , James Joseph LaLonde
- Applicant: Alex Cimpoia , James Joseph LaLonde
- Applicant Address: CA Laval, Quebec
- Assignee: SHIRE Canada Inc.
- Current Assignee: SHIRE Canada Inc.
- Current Assignee Address: CA Laval, Quebec
- Agency: Millen, White, Zelano & Branigan, P.C.
- International Application: PCT/CA03/01798 WO 20031118
- International Announcement: WO2004/048590 WO 20040610
- Main IPC: C12P41/00
- IPC: C12P41/00

Abstract:
The present invention relates to a process for producing compounds of formula (I) and (VII); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Pig Liver Esterase or Porcine Pancreatic Lipase b) recovering said compounds of formula (I) and (VII). The invention also provides a process for producing compounds of formula (III) and (X); said process comprising the steps of: a) subjecting a compound of formula (IV) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Candida Antarctica “A” lipase, Candida Antarctica “B” lipase, Candida Lypolitica Lipase or Rhizomucor Miehei Lipase b) recovering said compound of formula (III) and (X).
Public/Granted literature
- US20060134763A1 Stereoselective process for the production of dioxolane nucleoside analogues Public/Granted day:2006-06-22
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