Invention Grant
- Patent Title: Dual-acting pyrazole antihypertensive agents
- Patent Title (中): 双效吡唑抗高血压药
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Application No.: US12829667Application Date: 2010-07-02
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Publication No.: US07956054B2Publication Date: 2011-06-07
- Inventor: Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
- Applicant: Brooke Blair , Paul R. Fatheree , Melissa Fleury , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Michael Wilson
- Applicant Address: US CA South San Francisco
- Assignee: Theravance, Inc.
- Current Assignee: Theravance, Inc.
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Shelley Eberle
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; A61K31/44 ; A61K31/4155 ; A61K31/41 ; A61K31/415 ; A61K31/4245 ; C07D413/14 ; C07D401/14 ; C07D259/00 ; C07D271/06 ; C07D231/10
Abstract:
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
Public/Granted literature
- US20110009409A1 DUAL-ACTING PYRAZOLE ANTIHYPERTENSIVE AGENTS Public/Granted day:2011-01-13
Information query
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