Invention Grant
- Patent Title: Aryl-isoxazolo-4-yl-oxadiazole derivatives
- Patent Title (中): 芳基异恶唑-4-基 - 恶二唑衍生物
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Application No.: US12422317Application Date: 2009-04-13
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Publication No.: US07956074B2Publication Date: 2011-06-07
- Inventor: Bernd Buettelmann , Bo Han , Henner Knust , Andreas Koblet , Andrew Thomas
- Applicant: Bernd Buettelmann , Bo Han , Henner Knust , Andreas Koblet , Andrew Thomas
- Applicant Address: US NJ Nutley
- Assignee: Hoffman-La Roche Inc.
- Current Assignee: Hoffman-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Patricia S. Rocha-Tramaloni; Kimberly J. Prior
- Priority: EP05112956 20051223
- Main IPC: A61K31/422
- IPC: A61K31/422 ; A61K31/4245 ; C07D261/06 ; C07D271/10
Abstract:
The present invention is concerned with isoxazol-4-yl-oxadiazole derivatives of formula wherein R1, R2, and R3, are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. This class of compounds has high affinity and selectivity for GABA A α5 receptor binding sites and might be useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.
Public/Granted literature
- US20090197875A1 ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES Public/Granted day:2009-08-06
Information query
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