Invention Grant
- Patent Title: Ribonucleotide reductase inhibitors and methods of use
- Patent Title (中): 核糖核苷酸还原酶抑制剂及其使用方法
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Application No.: US12420713Application Date: 2009-04-08
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Publication No.: US07956076B2Publication Date: 2011-06-07
- Inventor: Yun Yen , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L Perkins Harki , Leila Su
- Applicant: Yun Yen , David Horne , Yate-Ching Yuan , Bing-Sen Zhou , Angela L Perkins Harki , Leila Su
- Applicant Address: US CA Duarte
- Assignee: City of Hope
- Current Assignee: City of Hope
- Current Assignee Address: US CA Duarte
- Agency: Perkins Coie LLP
- Agent Patrick Morris
- Main IPC: A61K31/426
- IPC: A61K31/426 ; A61K31/4168 ; C07D277/46 ; C07D233/88
Abstract:
Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 expression, such as for example certain cancer types, mitochondrial diseases, or degenerative diseases.
Public/Granted literature
- US20090258915A1 RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE Public/Granted day:2009-10-15
Information query
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