Invention Grant
- Patent Title: Fusion proteins with cleavable spacers and uses thereof
- Patent Title (中): 具有可切割间隔物的融合蛋白及其用途
-
Application No.: US12058648Application Date: 2008-03-28
-
Publication No.: US07956158B2Publication Date: 2011-06-07
- Inventor: Wei-Chiang Shen
- Applicant: Wei-Chiang Shen
- Applicant Address: US CA Los Angeles
- Assignee: University of Southern California
- Current Assignee: University of Southern California
- Current Assignee Address: US CA Los Angeles
- Agency: DLA Piper LLP (US)
- Main IPC: A61K38/12
- IPC: A61K38/12 ; A61K38/00
Abstract:
A polypeptide comprising a first protein domain, a second protein domain, and a dithiocyclopeptide spacer containing at least one protease cleavage site, wherein the dithiocyclopeptide is exogenous relative to the first or second protein domain, and wherein the first and second protein domains are operably linked by the dithiocyclopeptide. Also disclosed are methods of producing the polypeptide and delivering the protein domains into a cell.
Public/Granted literature
- US20080299612A1 FUSION PROTEINS WITH CLEAVABLE SPACERS AND USES THEREOF Public/Granted day:2008-12-04
Information query
IPC分类:
