Invention Grant
US07956201B2 Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one
有权
制备（S）-4-氟甲基 - 二氢 - 呋喃-2-酮的方法
- Patent Title: Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one
- Patent Title (中): 制备（S）-4-氟甲基 - 二氢 - 呋喃-2-酮的方法
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Application No.: US11873072Application Date: 2007-10-16
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Publication No.: US07956201B2Publication Date: 2011-06-07
- Inventor: Ulrich Zutter
- Applicant: Ulrich Zutter
- Applicant Address: US NJ Nutley
- Assignee: Hoffman-La Roche Inc.
- Current Assignee: Hoffman-La Roche Inc.
- Current Assignee Address: US NJ Nutley
- Agent George W. Johnston; Dennis P. Tramaloni; Samuel H. Megerditchian
- Priority: EP06123512 20061106
- Main IPC: C07D455/06
- IPC: C07D455/06 ; C07D307/20
Abstract:
The present invention relates to a process of the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one of the formula by employing a dialkylmalonate of the formula wherein R1b is lower alkyl, and the use of this process for the manufacture of DPP-IV inhibitors that are useful for the treatment and/or prophylaxis of diseases such as diabetes.
Public/Granted literature
- US20080108816A1 PROCESS FOR THE PREPARATION OF (S)-4-FLUOROMETHYL-DIHYDRO-FURAN-2-ONE Public/Granted day:2008-05-08
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