In high-frequency digital A/V cable having high-frequency signal line sets and low-frequency signal lines arranged in a parallel array, a metal shielding layer is set within an isolation layer inside the outer plastic sheath to surround the two high-frequency signal lines of each high-frequency signal line set for EMI protection, and a metal ground wire is arranged within the outer plastic sheath at one lateral side of the parallel array of the high-frequency signal line sets and low-frequency signal lines in a parallel manner.