A method of monitoring a patient's compliance with a medication regimen may include identifying a patient, identifying a medication prescribed to the patient and determining one or more intake times associated with the medication. For each intake time, an alert reminding the patient to take the medication may be generated, and the alert may be transmitted to a mobile device associated with the patient. Receipt of the alert by the mobile device may trigger one or more of an audible alarm, a visual alarm and a tactile alarm on the mobile device. If an indication of compliance is not received from the mobile device within a predefined period of time, a caregiver associated with the patient may be notified.