A system and method to generate an illustration of a cardiac region of interest of an imaged subject is provided. The method includes generating a three-dimensional model from a series of acquired images of the cardiac region of interest; measuring a series of values of at least one functional parameter of the cardiac region of interest; generating a map of a spatial relation of the plurality of values of the functional parameter in spatial relation to the three-dimensional model of the cardiac region of interest; generating a three-dimensional model of a vessel structure leading to the cardiac region of interest; generating an output image that includes combining the three-dimensional model of the cardiac region of interest, the map of the series of values of the functional parameter, and the three-dimensional model of the vessel structure in spatial relation to one another relative to a common coordinate system.