A drape for clean operation is a flexible bag-shaped structure for maintaining a substantially closed operating space around an operation site. The bag-shaped structure comprises a bottom wall 1 and a transparent top wall 2 and has a closed proximal end 100a and a closed distal end 100b. The bottom wall 1 is provided with at least one operation site-revealing opening 3 close to the proximal end, and the top wall 2 is provided with at least one pair of hand insertion parts 4 at a position close to the operation site-revealing opening 3 to allow the physician to aseptically insert the hands into the operating space, and a closed, openable and closable medical device supply port 5 for supplying medical devices required for operations at a position away from the operation site-revealing opening 3.