Invention Grant
- Patent Title: Methods for expression and purification of recombinant human growth hormone mutants
- Patent Title (中): 表达和纯化重组人生长激素突变体的方法
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Application No.: US11874068Application Date: 2007-10-17
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Publication No.: US07959926B2Publication Date: 2011-06-14
- Inventor: Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Sung Cho
- Applicant: Ying Buechler , Ricky Lieu , Michael Ong , Stuart Bussell , Nick Knudsen , Ho Sung Cho
- Applicant Address: US CA La Jolla
- Assignee: Ambrx, Inc.
- Current Assignee: Ambrx, Inc.
- Current Assignee Address: US CA La Jolla
- Agent John W. Wallen, III; Kristin S. Eaton
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K38/02 ; A61K38/27 ; C12P21/00 ; C07K1/16 ; C07H21/00
Abstract:
The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
Public/Granted literature
- US20080085538A1 Methods for Expression and Purification of Recombinant Human Growth Hormone Public/Granted day:2008-04-10
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