Invention Grant
US07960130B2 Method for activation of transient receptor potential cation channel, subfamily A, member 1 using acetaldehyde
有权
激活瞬时受体电位阳离子通道的方法，亚科A，使用乙醛的成员1
- Patent Title: Method for activation of transient receptor potential cation channel, subfamily A, member 1 using acetaldehyde
- Patent Title (中): 激活瞬时受体电位阳离子通道的方法，亚科A，使用乙醛的成员1
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Application No.: US12109256Application Date: 2008-04-24
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Publication No.: US07960130B2Publication Date: 2011-06-14
- Inventor: Sun Wook Hwang , Sang Su Bang
- Applicant: Sun Wook Hwang , Sang Su Bang
- Applicant Address: KR Seoul
- Assignee: Korea University Industry and Academy Cooperation Foundation
- Current Assignee: Korea University Industry and Academy Cooperation Foundation
- Current Assignee Address: KR Seoul
- Agency: Greenlee Sullivan P.C.
- Main IPC: G01N33/567
- IPC: G01N33/567 ; G01N33/52 ; G01N33/88 ; C12N5/0793
Abstract:
The present invention relates to a method for activation of TRPA1 (transient receptor potential cation channel, subfamily A, member 1) using acetaldehyde, more precisely a method for selecting a candidate for TRPA1 activation blocker from neurons activated by acetaldehyde. Acetaldehyde of the present invention works on TRPA1 specifically so that it facilitates the isolation of sensory neurons expressing TRPA1. Therefore, acetaldehyde of the invention can be effectively used for the studies on TRPA1 mechanisms and the development of a TRPA1 based anodyne.
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