Invention Grant
US07960345B2 Angiogenesis inhibitor comprising meteorin as an active ingredient
有权
血管生成抑制剂包含流星作为活性成分
- Patent Title: Angiogenesis inhibitor comprising meteorin as an active ingredient
- Patent Title (中): 血管生成抑制剂包含流星作为活性成分
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Application No.: US12376058Application Date: 2007-05-02
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Publication No.: US07960345B2Publication Date: 2011-06-14
- Inventor: Kyu-Won Kim
- Applicant: Kyu-Won Kim
- Applicant Address: KR Seoul
- Assignee: Snu R&DB Foundation
- Current Assignee: Snu R&DB Foundation
- Current Assignee Address: KR Seoul
- Agency: Greenlee Sullivan PC
- International Application: PCT/KR2007/002146 WO 20070502
- International Announcement: WO2008/136541 WO 20081113
- Main IPC: C07K14/515
- IPC: C07K14/515
Abstract:
The present invention relates to an angiogenesis inhibitor comprising meteorin as an active ingredient that is highly expressed in astrocytes of the brain and retina in the late embryonic stage and after the birth of a mouse. It is in particular highly detected in astrocyte endfeet surrounding blood vessels and promotes the expression of thrombospondin-1/-2 (TSP-1/-2) via autocrine pathway and thus inhibits angiogenesis. The meteorin of the present invention can be effectively used for pharmaceutical compositions and health foods that prevent vascular diseases by inhibiting angiogenesis.
Public/Granted literature
- US20100048471A1 ANGIOGENESIS INHIBITOR COMPRISING METEORIN AS AN ACTIVE INGREDIENT Public/Granted day:2010-02-25
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