Invention Grant
US07960346B2 Tumor cytotoxicity induced by modulators of the CXCR4 receptor
有权
由CXCR4受体的调节剂诱导的肿瘤细胞毒性
- Patent Title: Tumor cytotoxicity induced by modulators of the CXCR4 receptor
- Patent Title (中): 由CXCR4受体的调节剂诱导的肿瘤细胞毒性
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Application No.: US11979492Application Date: 2007-11-05
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Publication No.: US07960346B2Publication Date: 2011-06-14
- Inventor: Vincent C. Bond , James W. Lillard , Ming Bo Huang , Harvey Bumpers , Michael Powell
- Applicant: Vincent C. Bond , James W. Lillard , Ming Bo Huang , Harvey Bumpers , Michael Powell
- Applicant Address: US GA Atlanta
- Assignee: Morehouse School of Medicine
- Current Assignee: Morehouse School of Medicine
- Current Assignee Address: US GA Atlanta
- Agency: Andrews Kurth, LLP
- Agent Ping Wang
- Main IPC: A01N61/00
- IPC: A01N61/00 ; A61K38/00

Abstract:
The present invention provides a means of selectively killing epithelial cell carcinomas by administering a CXCR4-specific sequence of the Gp120 protein or Nef proteins or the proteins themselves (the modulators) such as that found in strains HIV-1, HIV-2, SIV, or FIV CXCR4-specific Gp 120 sequences or Nef proteins or sequences may be delivered to the mucosa or systemically. The mucosal means of application include oral, intranasal, ocular, intravaginal, rectal, and/or intraurethral administration in liquid or particulate form.
Public/Granted literature
- US20080227720A1 Tumor cytotoxicity induced by modulators of the CXCR4 receptor Public/Granted day:2008-09-18
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